12/19/2023 0 Comments Galactose anomeric carbon(2002) A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes. (1998) Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors. Mammen, M., Choi, S.-K., and Whitesides, G.(2010) Design and Creativity in Synthesis of Multivalent Neoglycoconjugates. (2008) Glycomimetics and Glycodendrimers as High Affinity Microbial Anti-adhesins. (2006) Glyconanoparticles: Types, synthesis and applications in glycoscience, biomedicine and material science. (2002) Biological applications of dendrimers. (2000) Chemical and enzymatic synthesis of glycopolymers. Essentials of glycobiology, Cold Spring Harbor Laboratory Press: New York, 1999. Varki, A., Cummings, R., Esko, J., Freeze, H., Hart, G.(1996) Glycobiology: Toward Understanding the Function of Sugars. These molecules can then be used in the construction of glycoconjugates to find applications in chemical biology. We describe here the syntheses of 2,3,4,6-tetra- O-acetyl-β- d-glucopyranosyl azide as well as 1-azido-3,6-dioxaoct-8-yl 2,3,4,6-tetra- O-acetyl-β- d-galactopyranoside and 1-azido-3,6-dioxaoct-8-yl 2,3,6,2′,3′,4′,6′-hepta- O-acetyl-β- d-lactoside. The azido moiety can be introduced either directly at the anomeric carbon of the carbohydrate derivative, or attached to a spacer arm. This so-called “click chemistry” methodology has now found numerous applications both in chemistry and biology. The recent development of copper(I)-catalyzed azide-alkyne cycloaddition (CuACC) paved the way to a novel conjugation strategy in which azido-functionalized carbohydrate derivatives can be readily connected to alkyne-functionalized (bio)molecules. As carbohydrates play a major role in numerous biological processes through their interactions with lectins and also appear as one of the most crucial post-translational modifications of proteins, chemists have developed several approaches for the design of glycoconjugates based on a series of conjugation methodologies.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |